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New dibenzocyclooctadiene lignans from the Kadsura ananosma |
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| Authors: | Jian-Hong Yang Hai-Yan ZhangXue Du Wei WangWei-Lie Xiao Jin WenJian-Xin Pu Xi-Can TangHan-Dong Sun |
| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China c Yunnan Academy of Forest Sciences, Institute of Tropical Forestry, Kunming 650204, People’s Republic of China d Graduate University of Chinese, Academy of Sciences, Beijing 100039, People’s Republic of China |
| Abstract: | Fourteen new dibenzocyclooctadiene lignans, ananonins A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of MS, NMR, and CD techniques. The biological activity of these compounds was evaluated, and ananonin M (13) showed moderate neuroprotective effects in an in vitro assay. |
| Keywords: | Kadsura ananosma Dibenzocyclooctadiene lignans Ananonins Neuroprotective effect |
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