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Tandem intramolecular oxa-Michael addition/decarboxylation reaction catalyzed by bifunctional cinchona alkaloids: facile synthesis of chiral flavanone derivatives |
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| Authors: | Hai-Feng WangHua Xiao Xiao-Wei WangGang Zhao |
| Affiliation: | a Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 LingLing Lu, Shanghai 200032, China b Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China |
| Abstract: | Bifunctional cinchona alkaloids were used to catalyze a tandem intramolecular oxa-Michael addition/decarboxylation reaction of alkylidene β-ketoesters 1, providing a series of flavanone derivatives with up to 97% yield and 93% ee. |
| Keywords: | Oxa-Michael addition Decarboxylation Enantioselectivity Bifunctional cinchona alkaloids Flavanones |
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