Copper/oxalohydrazide/ketone catalyzed synthesis of primary arylamines via coupling of aryl halides with aqueous ammonia in water |
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Authors: | Ying LiXinhai Zhu Fei MengYiqian Wan |
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Institution: | School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China |
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Abstract: | The coupling reaction of aryl halides with aqueous ammonia was catalyzed by copper/oxalohydrazide/ketone system in water to yield primary arylamines without inert atmosphere. This method was fast and facile. The coupling reaction proceeded at 90 °C for 20-80 min, or at room temperature for a prolonged reaction time. A variety of aryl bromides and iodides were found to be applicable to this three-component catalytic system, which afforded good to excellent isolated yields. |
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Keywords: | Copper Primary arylamine Water Coupling reaction |
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