Rhodium or palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehydonitrile to access 3-aryl and 3-alkenyl phthalides |
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| Authors: | Guanglei LvGenping Huang Guangyou ZhangChangduo Pan Fan Chen Jiang Cheng |
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| Affiliation: | a College of Chemistry and Materials Engineering, Chem. Dept., Wenzhou University, Wenzhou 325027, PR China
b Wenzhou Institute of Industry and Science, Wenzhou 325000, PR China |
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| Abstract: | A rhodium or palladium-catalyzed addition of boronic acids to phthalaldehydonitrile, followed by an intramolecular lactonization of cyano to access 3-substituted phthalides, is described. This procedure tolerates a series of functional groups, such as methoxy, fluoro, chloro, and vinyl groups. It is a novel procedure for the synthesis of 3-arylphthalides. |
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| Keywords: | Rhodium Palladium Phthalaldehydonitrile Lactonization Phthalides |
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