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Stereoselective total synthesis of (−)-cleistenolide |
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| Authors: | Dokuburra Chanti BabuJondoss Jon Paul Selavam Dorigondla Kumar ReddyVanam Shekhar Yenamandra Venkateswarlu |
| Affiliation: | Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology [IICT], Hyderabad 500 007, Andhra Pradesh, India |
| Abstract: | A stereoselective total synthesis of (−)-cleistenolide (1) derived from d-(−)-isoascorbic acid has been described. The new synthetic strategy involves highly diastereoselective reduction, one-pot protection of required benzoyl, acetyl groups, and the RCM reaction by using Grubbs catalyst are the key steps with considerable yields. |
| Keywords: | (&minus )-Cleistenolide Cleistochlamys kirkii smallcaps" >d-(&minus )-Isoascorbic acid K-Selectride Oxa-Micheal addition Grubbs RCM |
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