CuI-catalyzed Suzuki coupling reaction of organoboronic acids with alkynyl bromides |
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| Authors: | Shihua WangMin Wang Lei Wang Bo WangPinhua Li Jin Yang |
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| Affiliation: | a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, PR China
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China |
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| Abstract: | A CuI-catalyzed Suzuki cross-coupling reaction of organoboron derivatives with alkynyl bromides has been developed. In the presence of CuI (10 mol %) and 8-hydroxyquinoline (20 mol %), organoboron derivatives including aromatic and alkenyl boronic acids, potassium aryltrifluoroborates, and sodium tetraphenylborate reacted smoothly with 1-bromo-2-substituted acetylene to generate the corresponding cross-coupling products in good to excellent yields in C2H5OH. It is important to note that aromatic N,O-ligand 8-hydroxyquinoline is the most effective ligand for the reaction. |
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| Keywords: | CuI Suzuki coupling reaction Organoboronic acids Alkynyl bromides 8-Hydroxyquinoline |
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