Miyakosynes A-F, cytotoxic methyl branched acetylenes from a marine sponge Petrosia sp. |
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| Authors: | Yuki HitoraKentaro Takada Shigeru OkadaShigeki Matsunaga |
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| Affiliation: | Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan |
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| Abstract: | Cytototoxic linear acetylenes, miyakosynes A-F, were isolated from a marine sponge Petrosia sp. Their structures were elucidated by a combination of spectroscopic analyses and chemical methods. The absolute configuration of the secondary alcohols at each terminus was determined by the modified Mosher’s analysis. Miyakosynes show cytotoxicity against HeLa cells at submicromolar concentrations. |
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| Keywords: | Acetylene Sponge Cytototoxic Structure elucidation |
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