Palladium-catalyzed, asymmetric Baeyer-Villiger oxidation of prochiral cyclobutanones with PHOX ligands |
| |
| Authors: | Kimberly S PetersenBrian M Stoltz |
| |
| Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States |
| |
| Abstract: | Described in this report is a general method for the conversion of prochiral 3-substituted cyclobutanones to enantioenriched γ-lactones through a palladium-catalyzed Baeyer-Villiger oxidation using phosphinooxazoline ligands in up to 99% yield and 81% ee. Lactones of enantiopurity ≥93% could be obtained through a single recrystallization step. Importantly, 3,3-disubtituted cyclobutanones produced enantioenriched lactones containing a β-quaternary center. |
| |
| Keywords: | Baeyer-Villiger oxidation Phosphinooxazoline ligands Asymmetric catalysis Palladium |
| 本文献已被 ScienceDirect 等数据库收录！ |
