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An efficient one-pot synthesis of tetra-substituted pyrroles |
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| Authors: | Elmira GhabraieSaeed Balalaie Morteza BararjanianHamid Reza Bijanzadeh Frank Rominger |
| Institution: | a Peptide Chemistry Research Center, K.N. Toosi University of Technology, PO Box 15875-4416, Tehran, Iran b Department of Chemistry, Tarbiat Modares University, PO Box 141115-175, Tehran, Iran c Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany |
| Abstract: | The three-component reaction of primary amines, dialkyl acetylenedicarboxylates and β-nitrostyrene derivatives in the presence of Iron(III) chloride afforded 1,2,3,4-tetra-substituted pyrroles in high yields. These reactions could precede via domino Michael addition/cyclization process. |
| Keywords: | Tetra-substituted pyrrole Iron(III) chloride β-Nitrostyrene One-pot three-component reaction Enaminone |
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