Enantioselective total synthesis of macrosphelides A and E |
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| Authors: | Kavirayani R Prasad Phaneendra Gutala |
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| Institution: | Department of Organic Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560 012, Karnataka, India |
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| Abstract: | Enantioselective synthesis of 16-membered trilactone macrolides, macrosphelide A and E from (S)-lactic acid is described. Key features of the synthesis include the utility of a hitherto unexplored β-ketophosphonate derived from lactic acid and Yamaguchi lactonization leading to the title compounds. |
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| Keywords: | Total synthesis Macrolactone Lactic acid Macrosphelides |
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