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Microwave-mediated ‘click-chemistry’ synthesis of glycoporphyrin derivatives and in vitro photocytotoxicity for application in photodynamic therapy |
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| Authors: | Guillaume Garcia,Delphine Naud-Martin,Daniè le Carrez,Alain Croisy,Philippe Maillard |
| Affiliation: | a UMR 176 CNRS/Institut Curie, Institut Curie, Bât 110, Univ. Paris-Sud, F-91405 Orsay, France b Institut Curie, Section de Recherches, Centre Universitaire, Univ. Paris-Sud, F-91405 Orsay, France c GDR CNRS 3049 ‘Médicaments Photoactivables—Photochimiothérapie’ (PHOTOMED). Université Toulouse 3, UMR 5623 Université Paul Sabatier, F-31062 Toulouse Cedex 9, France d U749 INSERM, Curie, Bât 110, Univ. Paris-Sud, F-91405 Orsay, France |
| Abstract: | In this paper, we report the synthesis of a series of porphyrins, designed as photodynamic therapy (PDT) agents, substituted by three glycosyl units linked by a triazole group to chromophore in the aim to target tumor cells overexpressing lectin-type membrane receptors, by ‘click-chemistry’ under microwave heating. |
| Keywords: | Photodynamic therapy Porphyrin Carbohydrate Click-chemistry Phototoxicity Microwave-assisted synthesis |
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