A convenient route to functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides |
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| Authors: | Anne Breté ché Pascal Marchand,Marie-René e NourrissonPatrick Hautefaye,Guillaume De NanteuilMuriel Duflos |
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| Affiliation: | a Université de Nantes, Nantes Atlantique Universités, Laboratoire de Chimie Thérapeutique, Cibles et Médicaments des Infections, de l’Immunité et du Cancer, IICiMed UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, 44035 Nantes, France
b Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France |
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| Abstract: | The synthesis of novel functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl)oxy]acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo[3,2-b]pyridines. |
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| Keywords: | Functionalized furo[3,2-b]pyridines Ethyl 3-aminomethylfuro[3,2-b]pyridine-2-carboxylates 3-Amino-N-methylfuro[3,2-b]pyridine-2-carboxamides [6-Chloro-5-(2-ethoxy-2-oxoethoxy)pyridin-3-yl]benzoic acid Heteroannulation |
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