Stereoselective synthesis of polyoxygenated linear diaza-triquinanes via intramolecular 1,3-dipolar cycloaddition of sugar-derived hex-5-enals |
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| Authors: | Yunfeng LiYao Meng Xiangbao Meng Zhongjun Li |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China |
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| Abstract: | An efficient and stereoselective synthesis of diaza-triquinanes, the skeleton structures of many natural products, has been accomplished by intramolecular 1,3-dipolar cycloaddition of azomethine imine generated from sugar-derived hex-5-enal and pyrazolidin-3-one. |
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| Keywords: | Diaza-triquinane Carbohydrate Azomethine imine Intramolecular dipolar cycloaddition Stereoselective synthesis |
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