A Novel Formation of 3,4-Disubstituted Isothiazoles from 5-Amino-6-methylpyrimidinones |
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| Affiliation: | 1. M.V. Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1/3, Moscow 119991, Russia;2. Mendeleev University of Chemical Technology of Russia, Miusskaya Sq. 9, Moscow 125047, Russia |
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| Abstract: | 3,4-Disubstituted isothiazoles (8a, b, 9a, b, 10, 11, 14a,b) were synthesized from 5-amino-6-methyl-4(3H)-pynmidinone (1) or 1,3-disubstituted 5-amino-6-methyluracils (12a,b) via the formation of isothiazolo[4,3-d] pyrimidines (6, 13a, b) followed by the reaction with alkylamines. |
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