A direct preparation of 2-aryl-4-ethoxycarbonyl-3- pyrazolin-5-ones from aryl hydrazines |
| |
| Affiliation: | 1. Associate Professor of Organic Chemistry, Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, The Netherlands;2. Professor of Synthetic & Bio-organic Chemistry, VU University, Faculty of Sciences, Organic Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, The Netherlands;1. Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;2. DanPET AB, Malmö, Sweden;3. The Hevesy Laboratory, DTU Nutech, The Technical University of Denmark, Denmark;1. Department of Chemistry, Southern Federal University, 7, Zorge Str., 344090 Rostov-on-Don, Russian Federation;2. Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia;3. Southern Scientific Centre of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russian Federation;4. N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey;2. Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Basel CH-4002, Switzerland;3. University of Basel, Basel CH-4001, Switzerland |
| |
| Abstract: | Aryl hydrazines (1) possessing an electron-withdrawing substituent on the phenyl ring, on treatment with diethyl (ethoxymethylene)malonate in ethanolic sodium ethoxide solution, have directly afforded 2-aryl-4-ethoxy-carbonyl-3-pyrazolin-5-ones (4). Spectroscopic evidence is presented to differentiate these compounds (4) from their 1-aryl isomers (3). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
