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An enantioselective entry into the strychnos alkaloid skeleton
Affiliation:1. Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan;2. Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan;1. Custom Pharmaceutical Services, Dr. Reddys Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India;2. Department of Chemistry, Koneru Lakshmaiah University (KLU), Green Fields, Vaddeswaram, Guntur District, Andhra Pradesh 522502, India;3. Dr Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India;1. Key Laboratory of Microbial Pesticides, Ministry of Agriculture and Rural Affairs, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China;2. Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Huazhong University of Science and Technology, Wuhan 430074, China;3. Institute of Chemistry of New Materials of National Academy of Sciences of Belarus, Minsk 220141, Belarus;4. School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832004, China;1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi''an, 710069, PR China;2. Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi''an, 710032, PR China;3. Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University (900 Hospital of the Joint Logistics Team), Fuzhou, 350025, PR China
Abstract:A tryptophan derivative is used for the first time as a chiral precursor of Strychnos alkaloid skeleta. Removal of the extra carbon is presented and discussed.
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