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Stereospecific homologation of d-xylo and d-galacto dialdoses by 2-trimethylsilylthiazole
Affiliation:1. Virus Research and Development Laboratory, Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark;2. Danish Medicines Agency, Axel Heides Gade 1, 2300 Copenhagen S, Denmark;3. Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 5000 Odense C, Denmark;1. Dept. of Organic and Inorganic Chemistry, University of Oviedo, Julián Clavería 8, 33006, Oviedo, Spain;2. Dept. of Chemistry & QOPNA, University of Aveiro, 3810-193, Aveiro, Portugal;3. Dept. of Chemistry & Physics, University of Almería, 04120, Almería, Spain;1. Comprehensive ENETS Center, Medical and Surgical Oncology and Pathology, Istituto Nazionale Tumori (National Cancer Institute) IRCCS Foundation, via Venezian 1, 20133 Milan, Italy;2. University of Milan, Italy
Abstract:Homologation of the title dialdoses is carried out by diastereogenic addition of 2-trimethylsilylthiazole (1) to the side-chain aldehyde and unmasking the formyl group from thiazole ring; further addition of 1 to the resulting homologated dialdoses exhibited good levels of diastereoselectivity.
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