Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides

Institution:	1. Univ Paris Est Creteil and Université de Paris, CNRS, LISA, Créteil F-94010, France;2. Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen D-52074, Germany;3. Institut Universitaire de France (IUF), Paris F-75231, France;1. Zhejiang Pharmaceutical College, Ningbo, Zhejiang, China;2. Department of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China;3. Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, China;4. Hubei Biological Medicine Industrial Technological Institute Co., Ltd, China

Abstract:	The preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate (1) and Wadsworth- Emmons reaction with aldehydes and ketones is reported. Some of the products of these reactions were converted to unsaturated 3-oxomacrolides or 3-oxodiolides by transesterification in the presence of copper-(I)-trifluoroacetate.

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