Synthesis and biological activity of C-4 and C-15 Aryl azide derivatives of anguidine |
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| Affiliation: | 1. Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta 25 St., 30-059, Krakow, Poland;2. Department of Polymer Chemistry and Technology, Kaunas University of Technology, Radvilenu Plentas 19, LT50254, Kaunas, Lithuania;3. Institute of Chemistry, University of Silesia, 9 Szkolna St., 40-006, Katowice, Poland;1. School of Chemistry, The University of New South Wales, UNSW Sydney, NSW 2052, Australia;2. Department of Chemistry, Faculty of Art and Science, Namık Kemal University, Tekirdag, Turkey;3. Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli, Turkey |
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| Abstract: | Potential trichothecene photoaffinity reagents were prepared by coupling either the C-4 or C-15 alcohols derived from anguidine with (3-azido-5-methoxyphenoxy) acetic acid, 4-(3-azido-5-methoxyphenoxy)butyric acid, or N-(3-azido-5-methoxyphenyl) N'-(carboxymethyl) urea. The C-15 anguidine deriviatives of (3-azido-5-methoxyphenoxy)acetic acid and (3-azido-4-iodo-5-methoxyphenoxy) acetic acid possessed protein synthesis inhibition activity comparable to that of anguidine itself in Chinese hamster ovary and African Green Monkey kidney cell lines. |
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