Factors Influencing the Course of the Macrocyclization of α,ω‐Diamines with Esters of α,ω‐Dicarboxylic Acids |
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Authors: | Dorota Gryko,Daniel T. Gryko,Hanna Sierzputowska‐Gracz,Piotr Pia tek,Janusz Jurczak |
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Affiliation: | Dorota Gryko,Daniel T. Gryko,Hanna Sierzputowska‐Gracz,Piotr Pia̧tek,Janusz Jurczak |
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Abstract: | The efficient synthesis of eight new macrocyclic amides (lactams) via reaction of diesters with diamines under normal dilution conditions is described. The role of intermolecular H‐bond formation and steric hindrance is discussed based on 1H‐ and 15N‐NMR studies of appropriate model compounds. Principles for the optimal choice of esters that can be efficiently transformed into diamides have been developed. |
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