First total synthesis of murisolin |
| |
| Authors: | Maezaki Naoyoshi Tominaga Hiroaki Kojima Naoto Yanai Minori Urabe Daisuke Tanaka Tetsuaki |
| |
| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. |
| |
| Abstract: | The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
