| 苯二酚及氨基酚磷酰化衍生物的合成及NMR测定 |
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| 引用本文： | 陈晓岚,郁有祝,卢建莎,陈黎,屈凌波,廖新成,赵玉芬. 苯二酚及氨基酚磷酰化衍生物的合成及NMR测定[J]. 波谱学杂志, 2004, 21(1): 87-91 |
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| 作者姓名： | 陈晓岚 郁有祝 卢建莎 陈黎 屈凌波 廖新成 赵玉芬 |
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| 作者单位： | 郑州大学化学生物学重点实验室,郑州大学化学系,河南,郑州,450052;郑州大学化学生物学重点实验室,郑州大学化学系,河南,郑州,450052;教育部生命有机磷化学重点实验室,清华大学生命科学工程院,北京,100084 |
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| 基金项目： | 国家自然科学基金，河南省拨院士基金 |
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| 摘 要： | 以亚磷酸二乙酯为磷酰化试剂，通过Atherton-Todd反应分别对邻间对苯二酚和氨基苯酚6种化合物进行了磷酰化改造. 通过此方法得到了其相关磷酰化衍生物，并首次给出了相关磷酰化产物的波谱数据.
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| 关 键 词： | NMR 磷酰化 氨基苯酚 苯二酚 亚磷酸二乙酯(DEPH) ESI-MS |
| 文章编号： | 1000-4556(2004)01-0087-05 |
| 收稿时间： | 2003-06-10 |
| 修稿时间： | 2003-06-10 |
SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION |
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| CHEN Xiao-lan. SYNTHESIS OF PHOSPHORYLATED AMINOPHENOLS AND DIHYDROXYBENZENES BY THE ATHERON-TODD REACTION AND THEIR NMR CHARACTERIZATION[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 87-91 |
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| Authors: | CHEN Xiao-lan |
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| Affiliation: | 1.Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China; ;2.The Key Laboratory for Bioorganic Phosphorus Chemistry, the Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China |
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| Abstract: | The Atheron-Todd reaction has been applied extensively to the synthesis of phosphates and phosphoroamidates. In this study, aminophenols and dihydroxybenzenes were phosphoylated by a modified Atheron-Todd procedure, in which DEPH and tetrachloromethane were added to the mixed solution of phenol, triethylamine and dioxane and the mixed solution of phenols, triethylamine and dioxane, respectively. The target phosphates were obtained with good yields. Their structures were elucidated by NMR and ESI-MS. |
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| Keywords: | NMR ESI-MS |
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