Assignment of oxime and hydrazone configuration using 1H‐15N and 13C‐15N coupling measurements at natural abundance |
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| Authors: | Mike Kline Dawn Pierce Steve Cheatham |
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| Institution: | DuPont Crop Protection, Stine Haskell Research Center, Newark, DE, USA |
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| Abstract: | Measurement of 1H‐15N and 13C‐15N coupling constants at natural abundance is demonstrated to be a reliable and generic method to determine the configuration of oximes, hydrazines, and related systems. Data on 1H‐15N and 13C‐15N coupling constants on a variety of systems obtained at natural abundance confirm the geometric dependence of the measured 1H‐15N and 13C‐15N coupling constants. In addition, we summarize a simple “decision‐tree” for determining configuration based on practical considerations of sample quantity, solubility, and complexity. Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | 1H‐15N coupling constant HSQMBC HCNMBC 13C‐15N coupling constant oxime configuration |
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