川西獐牙菜醇提物对高脂血症模型小鼠的降血脂作用研究

目的：研究川西獐牙菜醇提物对小鼠高脂血症的影响.方法：将60只雄性昆明种小鼠随机分为正常对照组、模型组、阳性对照组、高、中、低剂量组,采用脂乳剂及饲料灌胃造模,连续喂养29天,分别测定小鼠血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）含量.结果：喂养29天后,阳性对照组、高、中、低剂量组对高脂模型血清的影响,表现为在TC水平上,分别极显著（P〈0.01）降低了约37%、51%、50%和70%,在TG水平上,分别极显著（P〈0.01）降低了约36%、50%、24%和12%,在HDL水平上,分别提高了约19%、5%、12%和14%,在LDL水平上,分别极显著（P〈0.01）降低了约36%、12%、18%和33%.结论：川西獐牙菜醇提物对小鼠高脂血症有明显的降血脂作用.

Experimental study on the antihyperlipidemia effect of ethanol extract of Swertia mussotii Franch in rat models with hyperlipidemia

Objective. To study the effects of decreasing blood lipid by extract from Swertia mussotii Franch in rat with hyperlipidemia. Methods： A total of 60 male rats of species of kunming were randomly divided into normal control group, model group, positive control group, high, medium and low -- dose group. The hyperlipidemia rat model was established by feeding with high- fat diet, and continuous feeding 29 days, respectively, the content of indexes as follows was measured, the total cholesterol（TC）, triglyceride（TG）,low density lipoprotein （LDL）and high density lipoprotein（HDL） in serum. Results： After feeding 29 days, the positive control group, high, medium and low -- dose group on the impact of serum high -- fat model, the performance of the TC level, respectively, significantly（P 〈 0. 01） were reduced about 37%, 51%, 50%, 70% in TG levels, respectively, significantly（P 〈 0.01）were reduced about 36%, 50%, 24%, 12%; in HDL levels, were increased about 19%, 5%, 12%, 14% in LDL levels, respectively, were decreased significantly（P〈 0.01）about 36%, 12%, 18%, 33%. Conclusions： Ethanol extracts of Swertia rnussotii Franch was significantly effective of antihyperlipidemia on rats with experimental hyperlipemia.