| 19F-NMR外标法测定盐酸左氧氟沙星中的氟含量 |
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| 引用本文： | 黄娟娟,杨明生,刘建庄.19F-NMR外标法测定盐酸左氧氟沙星中的氟含量[J].光谱实验室,2004,21(1):20-23. |
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| 作者姓名： | 黄娟娟 杨明生 刘建庄 |
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| 作者单位： | 湖南公安高等专科学院刑事科学技术系,长沙市,410006;湖南师范大学分析测试中心,长沙市,410081 |
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| 摘 要： | 本文研究了利用19F-NMR技术测定盐酸左氧氟沙星药物样品中氟的检测条件.优化了实验参数,选用三氟乙酸钠作内标,重水与去离子水混合液为溶剂.测定了对盐酸左氧氟沙星样品中氟含量.实验表明,氟的加标回收率在98.4%-100.6%之间,标准偏差为0.00214%-0.0489%,相对标准偏差小于1.124%.
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| 关 键 词： | 19F 核磁共振 盐酸左氧氟沙星 氟 |
| 文章编号： | 1004-8138(2004)01-0020-04 |
| 修稿时间： | 2003年6月13日 |
Determination of Fluorine in Levofloxacin medicine Sample by 19F Nuclear Magnetic Resonance |
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| HUANG Juan-Juan.Determination of Fluorine in Levofloxacin medicine Sample by 19F Nuclear Magnetic Resonance[J].Chinese Journal of Spectroscopy Laboratory,2004,21(1):20-23. |
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| Authors: | HUANG Juan-Juan |
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| Abstract: | A method was studied for the determination of fluorine in the sample of levofloxacin medicine by 19F-NMR technique.The operation conditions were researched and the instrument parameters were optimized.Sodium trifluoroacetate was used as a internal standards. The mixture of deutoxide and deionized water was used as solvent.Several samples were analyzed by this method. The average recovery rate of fluorine is 98.4% to 100.6%. The standard deviation is in the range of 0.00214% to 0.0489%,the relative standard deviation is less than 1.124%. |
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| Keywords: | F Nuclear Magnetic Resonance Levofloxacin Fluorine |
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