Synthesis of analogs of amathamide A and their preliminary antimicrobial activity |
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| Authors: | Ramírez-Osuna Moisés Chávez Daniel Hernández Lourdes Molins Elias Somanathan Ratnasamy Aguirre Gerardo |
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| Institution: | Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, BC, México. |
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| Abstract: | Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds. |
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