Microstructure and Chemical States of Hydroxyapatite/silk Fibroin Nanocomposites Synthesized via A Wet-mechanochemical Route |
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Authors: | Wang Li Nemoto Rei Senna Mamoru |
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Institution: | (1) Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama, 223-8522, Japan |
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Abstract: | Hydroxyapaptite (HAp)/silk fibroin (SF) nanocomposites were prepared via a wet-mechanochemical route at room temperature. The results reveal that the inorganic phase in the composites is carbonate-substituted HAp containing 2.9–3.1 wt% of carbonate ions. The primary HAp crystals are rod-like in shape with a typical size of 20–30 nm in length and 8–10 nm in width, and lattice parameters a = 9.423![thinsp](/content/r2442hr62t1l4150/xxlarge8201.gif) , c = 6.888![thinsp](/content/r2442hr62t1l4150/xxlarge8201.gif) . The self-assembled HAp crystals along their c-axes aggregate into bundles, which are connected with SF fibrils. Consequently, a three-dimensional porous network is formed in the composite, which is beneficial to inducing new bone formation in practical implantation. |
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Keywords: | hydroxyapatite silk fibroin porous nanocomposite microstructure chemical state bone substitute |
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