One-step biomimetic synthesis of (±)-linderaspirone A and (±)-bi-linderone |
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| Authors: | Gang-Qiang Wang Kun WeiLin Zhang Tao FengFei Wang Qiu-An WangJi-Kai Liu |
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| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China
b School of Chemistry and Chemical Engineering of Hunan University, Changsha 410082, Kunming 650204, People’s Republic of China |
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| Abstract: | A one-step biomimetic synthesis of racemic linderspirone and bi-liderone from methyllinderone has been achieved, which probably reflects the biosynthesis of the natural products. There are few naturally occurring substances that appear to be formed by a 4+4] or 4+2] cycloaddition. We proposed that the 4+4] dimerization of methyllinderone proceeds via a stepwise mechanism involving a diradical intermediate. |
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| Keywords: | Biomimetic Synthesis Linderspirone Bi-liderone Methyllinderone |
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