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Synthesis of new spin labels for Cu-free click conjugation |
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| Authors: | Tamás KálaiMark R Fleissner József Jek?Wayne L Hubbell Kálmán Hideg |
| Institution: | a Department of Organic and Medicinal Chemistry, University of Pécs, H-7602 Pécs, PO Box 99, Hungary b Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90095-7008, USA c Department of Chemistry, College of Nyíregyháza, H-4440 Nyíregyháza, Sóstói st. 31/B, Hungary |
| Abstract: | New pyrroline nitroxides attached to a terminal acetylenic sulfone, a dibenzocyclooctyne or a cyclooctyne carboxylic acid were synthesized and tested in Cu-free click reactions to conjugate these new spin labels with 4-azido-TEMPO, azidophenylalanine and an azidophenylalanine-containing protein. |
| Keywords: | Amino acids Acetylenes Click chemistry Free radicals Spin labeling |
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