Purine nucleoside analogs. 6. Chlorination of acycloguanosine and some of its derivatives with thionyl chloride |
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Authors: | M A Madre R A Zhuk M Yu Lidak |
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Institution: | (1) Institute of Organic Synthesis, Latvian Academy of Sciences, 226006 Riga |
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Abstract: | The reaction of 9- and 7-(2-hydroyethoxymethyl)guanines and some of their derivatives with thionyl chloride inhexamethylphosphorustriamide was investigated. 9- and 7-(2-Chloroethoxymethyl)- and 8-chloro-, 8-bromo-, and 8-mercapto-9-(2-chloroethoxymethyl)guanines were synthesized. The structure of the compounds was confirmed by the UV and ESR spectra.See 1] for Communication 5.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 671–673, May, 1992. |
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