Synthesis of 5-methylfuro[3,2-b]pyridine-2-carboxylic acid |
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Authors: | C D Weis |
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Abstract: | Oxidation of 3-hydroxy-6-methyl-2-hydroxymethylpyridine with manganese dioxide yielded the corresponding aldehyde, the condensation of which with diethyl bromomalonate furnished hydroxydihydrofuro3,2-b]pyridinediearboxylie acid ester. Saponification of the diester with concentrated hydrochloric acid afforded the hydrochloride of 5-methylfuro3,2-b]pyrjdine car-boxylic acid. |
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