| 苄基异喹啉生物碱Neolitacumonine、Mollinedine和Papaverine的全合成 |
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| 引用本文： | 孙勉勉,李风雷,何云刚,朱星亮,刘世领,施小新.苄基异喹啉生物碱Neolitacumonine、Mollinedine和Papaverine的全合成[J].有机化学,2020(1):149-155. |
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| 作者姓名： | 孙勉勉 李风雷 何云刚 朱星亮 刘世领 施小新 |
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| 作者单位： | 华东理工大学药学院;青平药业有限公司 |
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| 基金项目： | 国家自然科学基金(Nos.20972048,20172015)资助项目。 |
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| 摘 要： | 研究了苄基异喹啉生物碱的一条新的通用合成路线.其关键步骤为1-苄基-3,4-二氢异喹啉的铜催化氧化芳构化串联反应.以胡椒醛或3,4-二甲氧基苯甲醛为起始原料,经8步反应,分别以42%、37%和37%的总收率实现了三个苄基异喹啉生物碱Neolitacumonine、Mollinedine和Papaverine的全合成.
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| 关 键 词： | 苄基异喹啉生物碱 Neolitacumonine Mollinedine PAPAVERINE |
Total Syntheses of Benzylisoquinoline Alkaloids Neolitacumoine,Mollinedine and Papaverine |
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| Sun Mianmian,Li Fenglei,He Yungang,Zhu Xingliang,Liu Shiling,Shi Xiaoxin.Total Syntheses of Benzylisoquinoline Alkaloids Neolitacumoine,Mollinedine and Papaverine[J].Chinese Journal of Organic Chemistry,2020(1):149-155. |
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| Authors: | Sun Mianmian Li Fenglei He Yungang Zhu Xingliang Liu Shiling Shi Xiaoxin |
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| Institution: | (Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237;Qingping Pharmaceutical Co,Ltd,Shanghai 201710) |
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| Abstract: | A new general synthetic route towards benzylisoquinoline alkaloids was developed. The key step of this route is Cu-catalyzed cascade oxidation-aromatization of 1-benzyl-3,4-dihydroisoquinolines. The three benzylisoquinoline alkaloids such as neolitacumonine, mollinedine and papaverine were synthesized starting from piperonaldehyde and 3,4-dimethoxybenzaldehyde by 8 steps in 42%, 37% and 37% overall yields, respectively. |
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| Keywords: | benzylisoquinoline alkaloids neolitacumonine mollinedine papaverine |
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