| 氮杂环卡宾催化下官能化萘并吡喃酮的串联合成 |
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| 引用本文： | 李莎,徐嘉煜,罗鲜,杨雯涵,姚昌盛.氮杂环卡宾催化下官能化萘并吡喃酮的串联合成[J].有机化学,2020(2):470-477. |
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| 作者姓名： | 李莎 徐嘉煜 罗鲜 杨雯涵 姚昌盛 |
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| 作者单位： | 江苏省功能材料绿色合成重点实验室江苏师范大学化学与材料科学学院 |
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| 基金项目： | 国家自然科学基金(Nos.21871113,21372101)资助项目. |
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| 摘 要： | 在氮杂环卡宾(NHC)催化下,查尔酮衍生物与α-溴代烯醛经过"Michael加成-Michael加成-内酯化"等串联过程,一步合成了官能化萘并吡喃酮.该方法具有产率高、底物易得和条件温和等优点,为萘并吡喃酮的高效构建和官能化提供了新思路.
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| 关 键 词： | 氮杂环卡宾(NHC) α-溴代烯醛 查尔酮衍生物 官能化萘并吡喃酮 串联反应 |
Efficient N-Heterocyclic Carbene-Catalyzed Cascade Synthesis of Functionalized Naphthopyranone |
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| Li Sha,Xu Jiayu,Luo Xian,Yang Wenhan,Yao Changsheng.Efficient N-Heterocyclic Carbene-Catalyzed Cascade Synthesis of Functionalized Naphthopyranone[J].Chinese Journal of Organic Chemistry,2020(2):470-477. |
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| Authors: | Li Sha Xu Jiayu Luo Xian Yang Wenhan Yao Changsheng |
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| Institution: | (Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials,School of Chemistry and Materials Science,Jiangsu Normal University,Xuzhou 221116) |
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| Abstract: | An efficient N-heterocyclic carbene(NHC)-catalyzed "Michael-Michael-Lactonization" cascade process involving chalcone derivatives and α-bromoenals for the syntheses of functionalized naphthopyranones was disclosed. This approach was qualified with good yields, readily available starting materials and mild reaction conditions. |
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| Keywords: | N-heterocyclic carbene (NHC) α-bromoenals chalcone derivatives functionalized naphthopyranone cascade reaction |
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