| 一种基于协同效应的肼荧光探针及其在细胞成像中的应用 |
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| 引用本文： | 胥稳智,李雪,韩孟楠,周婷婷,杨瑜涛,李玮.一种基于协同效应的肼荧光探针及其在细胞成像中的应用[J].有机化学,2020(1):181-185. |
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| 作者姓名： | 胥稳智 李雪 韩孟楠 周婷婷 杨瑜涛 李玮 |
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| 作者单位： | 河北大学化学与环境科学学院 |
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| 基金项目： | 国家自然科学基金(Nos.21702043,21807021)资助项目。 |
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| 摘 要： | 开发了一种基于协同效应的新型肼荧光探针.通过在发色团上引入两种不同的识别位点,双识别位点的协同效应使得该探针对肼具有良好的专一性和灵敏度,检测限可达0.05~10.0μmol·L^-1.此外,该探针还可用于细胞(Bt-474)中肼的检测.
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| 关 键 词： | 水合肼 协同效应 细胞成像 荧光探针 |
A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging |
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| Xu Wenzhi,Li Xue,Han Mengnan,Zhou Tingting,Yang Yutao,Li Wei.A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging[J].Chinese Journal of Organic Chemistry,2020(1):181-185. |
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| Authors: | Xu Wenzhi Li Xue Han Mengnan Zhou Tingting Yang Yutao Li Wei |
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| Institution: | (Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry&Environmental Science,Hebei University,Baoding,Hebei 071002) |
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| Abstract: | Hydrazine is an important raw material and catalyst in chemical industry. However, hydrazine is very harmful to human organs. A new type of probe was developed based on the synergistic effect. Two recognition sites were introduced into the probe to improve performance to hydrazine, which has good specificity to hydrazine. The limit of detection(LOD) for N2 H4 was 0.05~10.0 μmol·L^-1. Moreover, the probe could detect N2 H4 in BT-474 cells. |
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| Keywords: | hydrazine synergistic effect cell imaging fluorescent probe |
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