| 铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应 |
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| 引用本文： | 郭圆圆,刘振伟,朱明祥,李琳琳,李敬亚,邹大鹏,吴豫生,吴养洁. 铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应[J]. 有机化学, 2020, 0(3): 724-730 |
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| 作者姓名： | 郭圆圆 刘振伟 朱明祥 李琳琳 李敬亚 邹大鹏 吴豫生 吴养洁 |
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| 作者单位： | 郑州大学化学与分子工程学院;郑州泰基鸿诺医药股份有限公司 |
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| 基金项目： | 国家自然科学基金(Nos.21172200.21702191)资助项目. |
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| 摘 要： | 报道了利用廉价易得的二甲基亚砜作为甲硫基源,实现8-氨基喹啉导向的芳基酰胺的二甲硫基化反应.利用CuSO4·5H2O作为促进剂,以中等到较好的收率高效地合成了一系列含有二甲硫基的芳酰胺衍生物.此外,该反应体系具有反应条件温和、不需要外加其它氧化剂的特点.
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| 关 键 词： | 二甲硫基化 二甲基亚砜 8-氨基喹啉 Cu促进 |
Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group |
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| Guo Yuanyuan,Liu Zhenwei,Zhu Mingxiang,Li Linlin,Li Jingya,Zou Dapeng,Wu Yusheng,Wu Yangjie. Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group[J]. Chinese Journal of Organic Chemistry, 2020, 0(3): 724-730 |
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| Authors: | Guo Yuanyuan Liu Zhenwei Zhu Mingxiang Li Linlin Li Jingya Zou Dapeng Wu Yusheng Wu Yangjie |
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| Affiliation: | (College of Chemistiy and Molecular Engineerings Zhengzhou University,Zhengzhou 450052;Tetranov Biopharm,LLC,Zhengzhou 450052) |
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| Abstract: | Cu(Ⅱ)-promoted dimethylthiolation of C(sp2)一H bonds using DMSO as the methylthiolation source with the assista nee of an 8-aminoquinoline directing group have been developed.A number of dimethylthiolated benzamides were efficiently synthesized using CuSO4e5H2O as a promoter in moderate to good yields.In addition,this reaction system features facile conditions and no other oxidant additive was required. |
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| Keywords: | Dimethylthiolation DMSO 8-Aminoquinoline Copper-promoted |
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