Synthesis of magnetic nanoparticles and their application to bioassays |
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| Authors: | Tetsuya Osaka Tadashi Matsunaga Takuya Nakanishi Atsushi Arakaki Daisuke Niwa Hironori Iida |
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| Affiliation: | (1) Department of Applied Chemistry, Waseda University, 3-4-1 Okubo, Shinjuku Tokyo, 169-8555, Japan;(2) Institute for Biomedical Engineering, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku Tokyo, 162-0041, Japan;(3) Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei Tokyo, 184-8588, Japan |
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| Abstract: | Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles. |
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| Keywords: | Magnetic nanoparticle Iron oxide Surface modification Biomolecule detection Patterned surface |
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