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Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries |
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| Authors: | Taegwan Kim Min Woo Ha Jonghoon Kim |
| Institution: | 1.Department of Chemistry, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea;2.Integrative Institute of Basic Science, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea;3.Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Korea;4.Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Korea |
| Abstract: | Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries. |
| Keywords: | natural products indole small-molecule library diversity-oriented synthesis complexity-to-diversity (Ctd) strategy biomimetic synthesis |