Advances in the Biological Application of Force-Induced Remnant Magnetization Spectroscopy |
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| Authors: | Shuyu Liao Mengxue Sun Jinxiu Zhan Min Xu Li Yao |
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| Institution: | 1.State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing 100190, China; (S.L.); (M.S.); (J.Z.); (M.X.);2.School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Biomolecules participate in various physiological and pathological processes through intermolecular interactions generally driven by non-covalent forces. In the present review, the force-induced remnant magnetization spectroscopy (FIRMS) is described and illustrated as a novel method to measure non-covalent forces. During the FIRMS measurement, the molecular magnetic probes are magnetized to produce an overall magnetization signal. The dissociation under the interference of external force yields a decrease in the magnetic signal, which is recorded and collected by atomic magnetometer in a spectrum to study the biological interactions. Furthermore, the recent FIRMS development with various external mechanical forces and magnetic probes is summarized. |
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| Keywords: | non-covalent bonds molecular and cellular interactions FIRMS mechanical force magnetic probe |
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