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Analysis of Vicinal Water in Soft Contact Lenses Using a Combination of Infrared Absorption Spectroscopy and Multivariate Curve Resolution |
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| Authors: | Shoichi Maeda Shunta Chikami Glenn Villena Latag Subin Song Norio Iwakiri Tomohiro Hayashi |
| Institution: | 1.Department of Material Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsuta-Cho Midori-Ku, Yokohama 226-8502, Japan; (S.M.); (S.C.); (G.V.L.); (S.S.);2.Life Science Products Division, NOF Corporation, Yebisu Garden Place Tower, 20-3 Ebisu 4-Chome, Shibuya-Ku, Tokyo 150-6019, Japan;3.The Institute for Solid State Physics, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa 277-0882, Japan |
| Abstract: | In this paper, we propose a new spectroscopic method to explore the behavior of molecules near polymeric molecular networks of water-containing soft materials such as hydrogels. We demonstrate the analysis of hydrogen bonding states of water in the vicinity of hydrogels (soft contact lenses). In this method, we apply force to hydrated contact lenses to deform them and to modulate the ratio between the signals from bulk and vicinal regions. We then collect spectra at different forces. Finally, we extracted the spectra of the vicinal region using the multivariate curve resolution-alternating least square (MCR-ALS) method. We report the hydration states depending on the chemical structures of hydrogels constituting the contact lenses. |
| Keywords: | infrared absorption spectroscopy molecular vibration soft contact lenses water multivariate curve resolution hydrogel soft material |