Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation,Optimization and In Vivo Characterization |
| |
| Authors: | Amarjitsing Rajput Riyaz Ali M Osmani Achyut Khire Sanket Jaiswal Rinti Banerjee |
| |
| Institution: | 1.Nanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, India; (A.K.); (S.J.); (R.B.);2.Department of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth Deemed University, Pune 411038, India;3.Department of Pharmaceutics, JSS College of Pharmacy (JSSCP), JSS Academy of Higher Education & Research (JSS AHER), Mysuru 570015, India |
| |
| Abstract: | Background: The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception. Methods: Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied. Results: The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (−23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days. Conclusion: The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch. |
| |
| Keywords: | drug delivery nanotechnology contraception levonorgestrel liposomes microneedle sustained-release |
|
|
