Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C,D, F,and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence |
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| Authors: | Marco Kruppa Gereon A Sommer Thomas J J Müller |
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| Institution: | Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany; (M.K.); (G.A.S.) |
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| Abstract: | N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence. This methodology was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield. |
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| Keywords: | natural products one-pot reactions alkaloids Masuda borylation– Suzuki coupling |
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