Synthesis of Pyridoxine-Derived Dimethylpyridinols Fused with Aminooxazole,Aminoimidazole, and Aminopyrrole |
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Authors: | Bhuwan Prasad Awasthi Hyunji Lee Byeong-Seon Jeong |
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Affiliation: | 1.College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea;2.Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA |
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Abstract: | Described in this paper are studies on the preparation of three classes of dimethylpyridinols derived from pyridoxine fused with aminooxazole, aminoimidazole, and aminopyrrole. The key feature of this synthetic strategy is the manipulation of hydroxymethyl moiety of C(5)-position of the pyridoxine starting material along with the installation of an amino group at C(6)-position. Efficient and practical synthesis for the oxazole- and imidazole-fused targets was accomplished, while the instability of the pyrrole-fused one was observed. |
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Keywords: | aminobicyclic pyridinols pyridoxine oxazole imidazole pyrrole |
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