Pentacyclic Triterpenoids from Sabia discolor Dunn and Their α-Glycosidase Inhibitory Activities |
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| Authors: | Jin-Hong Ma Dan Hu Lu-Lu Deng Jiang Li Xiao-Jiang Hao Shu-Zhen Mu |
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| Institution: | 1.State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; (J.-H.M.); (D.H.); (L.-L.D.); (J.L.); (X.-J.H.);2.The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China;3.School of Pharmacy, Guizhou Medical University, Guiyang 550025, China;4.Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650201, China |
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| Abstract: | Four new pentacyclic triterpenoids named Sabiadiscolor A–D (1 and 7–9) together with eleven known ones were isolated by repeated column chromatography. Their structures were identified and characterized by NMR and MS spectral data as 6 oleanane-type pentacyclic triterpenoids (1–6), 7 ursane-type ones (7–13), and 2 lupanane-type ones (14–15). Except for compound 15, all other compounds were isolated from Sabia discolor Dunn for the first time. Their α-glycosidase inhibitory activities were evaluated, which showed that compounds 1, 3, 8, 9, 13, and 15 implied remarkable activities with IC50 values ranging from 0.09 to 0.27 μM, and the preliminary structure–activity relationship was discussed. |
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| Keywords: | Sabia discolor Dunn pentacyclic triterpenoids isolation and purification α -glycosidase inhibitory activities |
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