Catalytic enantioselective Diels-Alder reactions using titanium complexes of cis-N-sulfonyl-2-amino-1-indanols |
| |
| Authors: | E J Corey Thomas D Roper Kazuaki Ishihara and Georgios Sarakinos |
| |
| Institution: | Department of Chemistry, Harvard University, Cambridge, Massachusetts, 02138 U.S.A. |
| |
| Abstract: | A titanium complex derived from (1R, 2S)-N-(2,4,6-trimethylbenzenesulfonyl)-2-amino-1-indanol catalyzes the Diels-Alder reaction of 2-bromoacrolein and cyclopentadiene with 96.5:3.5 enantioselectivity. A new and efficient synthesis of 2-amino-1-indanol (6) contributes to the potential of this methodology. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
