| 拟肾上腺素药盐酸甲氧明的绿色合成 |
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| 引用本文： | 谢宇,胡金刚,贾杰,洪小伟,魏娅. 拟肾上腺素药盐酸甲氧明的绿色合成[J]. 有机化学, 2010, 30(2): 282-284 |
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| 作者姓名： | 谢宇 胡金刚 贾杰 洪小伟 魏娅 |
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| 作者单位： | 南昌航空大学环境与化学工程学院,南昌,330063 |
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| 基金项目： | 国家自然科学基金，江西省自然科学基金，江西省教育厅科技，航空高校基金 |
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| 摘 要： | 以对苯二酚为原料经羟基的甲基化、傅克酰基化、肟化、肟基还原、酮胺氢化5步反应合成了盐酸甲氧明, 中间体和目标产物经核磁共振氢谱、红外光谱及元素分析仪确证了其化学结构, 总收率为37.6%. 与传统盐酸甲氧明工艺相比, 该工艺反应条件温和、简便、经济、产率高及对环境友好.
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| 关 键 词： | 甲氧明 甲基化 肟化 还原 绿色合成 |
| 收稿时间： | 2009-02-25 |
| 修稿时间： | 2009-08-04 |
Green Synthesis of the Adrenomimetic Drug Methoxamine Hydrochloride |
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| Xie Yu,Hu Jingang,Jia Jie,Hong Xiaowei,Wei Ya. Green Synthesis of the Adrenomimetic Drug Methoxamine Hydrochloride[J]. Chinese Journal of Organic Chemistry, 2010, 30(2): 282-284 |
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| Authors: | Xie Yu Hu Jingang Jia Jie Hong Xiaowei Wei Ya |
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| Affiliation: | (School of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063) |
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| Abstract: | Methoxamine hydrochloride was synthesized from p-dihydroxybenzene by O-methylation, Friedel-Crafts acylation, oximation reaction, oxime reduction and keto-amine hydrogenation reactions. All intermediates and products were characterized by IR, 1H NMR spectra and elemental analysis. The total yield was 37.6%. Compared to the traditional synthetic procedures of methoxamine hydrochloride, the procedures were temperate, convenient, economical, high-yielding and environment-friendly. |
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| Keywords: | methoxamine methylation oximation reduction green synthesis |
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