Protein model refinement using structural fragment tessellation |
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Authors: | Jonassen Inge Klose Daniel Taylor William R |
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Institution: | Computational Biology Unit and Department of Informatics, University of Bergen, Norway. |
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Abstract: | A method is described for the refinement of rough protein models based on finding a selection of structural fragments that match the model. Unlike most fragment-based methods, these are not necessarily contiguous in the sequence and form a tiling (tessellation) that covers most of the structure. The residue positions of the fragments are then used as a target for the model atoms to generate a revised model which is used as the basis of a subsequent pattern definition and search. The method was shown to improve the recognition of the native fold in a series of decoys largely as a result of improved secondary structure representation. |
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Keywords: | Protein structure prediction Molecular modelling |
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