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Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation |
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| Authors: | Judith Buddensiek Alexander Dressel Michael Kowalski Uwe Runge Henry Schroeder Andreas Hermann Matthias Kirsch Alexander Storch Michael Sabolek |
| Affiliation: | (1) Department of Neurology, Ernst Moritz Arndt University of Greifswald, 17475 Greifswald, Germany;(2) Department of Neurosurgery, Ernst Moritz Arndt University of Greifswald, 17475 Greifswald, Germany;(3) Department of Neurology and Centre for Regenerative Therapies Dresden (CRTD), Dresden University of Technology, 01307 Dresden, Germany;(4) Department of Neurosurgery, Dresden University of Technology, 01307 Dresden, Germany |
| Abstract: | BackgroundNeural stem cells (NSCs) are a promising source for cell replacement therapies for neurological diseases. Growing evidence suggests an important role of cerebrospinal fluid (CSF) not only on neuroectodermal cells during brain development but also on the survival, proliferation and fate specification of NSCs in the adult brain. Existing in vitro studies focused on embryonic cell lines and embryonic CSF. We therefore studied the effects of adult human leptomeningeal CSF on the behaviour of adult human NSCs (ahNSCs). |
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