Influence of mechanical treatment on the properties of betulin,betulin diacetate,and their mixture with water-soluble polymers |
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| Authors: | M A Mikhailenko T P Shakhtshneider V A Drebushchak S A Kuznetsova G P Skvortsova V V Boldyrev |
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| Institution: | (1) Institute of Solid-State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, ul. Kutateladze, 18, Novosibirsk, 630128, Russia;(2) Scientific-Educational Center Molecular Design and Ecologically Safe Technologies of Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russia;(3) Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, prosp. Akad. Koptyuga, 3, Novosibirsk, 630090, Russia;(4) Institute of Chemistry and Chemical Engineering, Siberian Branch, Russian Academy of Sciences, ul. K. Marksa, 42, Krasnoyarsk, 660049, Russia |
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| Abstract: | The influence of mechanical treatment on the properties of betulin, betulin diacetate, and their mixture with water-soluble
polymers was studied. It was shown that mechanical treatment in a planetary mill-activator disordered the crystalline structure
of betulin and betulin diacetate. Composites of betulin with polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG) that
gave an increased betulin concentration upon dissolution in water were prepared. It was shown that H-bonds formed between
betulin and PVP upon mechanical activation of their mixtures. |
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