Seasonal variations of the composition,structural features,and antitumor properties of polysaccharides from <Emphasis Type="Italic">Padina pavonica</Emphasis> (Lebanon) as a function of composition |
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Authors: | R V Men’shova S P Ermakova S M Rachidi A H Al-Hajje T N Zvyagintseva H M Kanaan |
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Institution: | 1.Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences,Vladivostok,Russia;2.Laboratory of Biotechnology of Natural Substances and Health Products, Faculty of Pharmacy,Lebanese University,Beirut,Lebanon |
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Abstract: | The variation of the polysaccharide composition of the brown alga Padina pavonica from the Mediterranean Sea was studied as a function of the collection season (April–July). It was shown that the principal
polysaccharide (8.0-13.3% of dry alga weight) was alginic acid. Its content did not undergo significant changes from April
to July. The content of water-soluble polysaccharides (laminarans and fucoidans) was low (<0.3% of dry alga weight). Water-soluble
polysaccharides of the studied alga were practically pure fucoidan. The amount of laminarans was insignificant (<0.01% of
dry alga weight). The content of fucoidans increased in alga samples from May through July. It was shown that P. pavonica is a promising source of alginic acids, which have a high capacity for gelation, and fucoidans, which exhibit antitumor action
against RPMI-7951 human melanoma cells. |
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