| Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety |
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| 引用本文： | 杨松 高兴文 刁春玲 宋宝安 金林红 徐广芳 张国平 王伟 胡德禹 薛伟 周霞 卢平. Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety[J]. 中国化学, 2006, 24(11): 1581-1588. DOI: 10.1002/cjoc.200690296 |
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| 作者姓名： | 杨松 高兴文 刁春玲 宋宝安 金林红 徐广芳 张国平 王伟 胡德禹 薛伟 周霞 卢平 |
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| 作者单位： | Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, Guizhou 550025, China |
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| 基金项目： | Project supported by the National Key Program for Basic Research （Nos. 2003CB114404, 2005CCA01500）, the National Natural Science Foundation of China （No. 20362004） and the Doctoral Program Foundation of the Ministry of Education, China （No. 20040657003）. |
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| 摘 要： | Chiral α-aminophosphonates were synthesized using （R） or （S）-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.
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| 关 键 词： | 手性氨基膦酸酯 氟半族 抗真菌活性 微波照射 合成 |
| 收稿时间： | 2006-04-25 |
| 修稿时间： | 2006-04-252006-06-24 |
Synthesis and Antifungal Activity of Novel Chiral α‐Aminophosphonates Containing Fluorine Moiety |
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| YANG, Song, GAO, Xing-Wen, DIAO, Chun-Ling, SONG, Bao-An, JIN, Lin-Hong, XU, Guang-Fang, ZHANG, Guo-Ping, WANG, Wei, HU, De-Yu, XUE, Wei, ZHOU, Xia, LU, Ping. Synthesis and Antifungal Activity of Novel Chiral α‐Aminophosphonates Containing Fluorine Moiety[J]. Chinese Journal of Chemistry, 2006, 24(11): 1581-1588. DOI: 10.1002/cjoc.200690296 |
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| Authors: | YANG Song GAO Xing-Wen DIAO Chun-Ling SONG Bao-An JIN Lin-Hong XU Guang-Fang ZHANG Guo-Ping WANG Wei HU De-Yu XUE Wei ZHOU Xia LU Ping |
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| Abstract: | Chiral α‐aminophosphonates were synthesized using (R) or (S)‐1‐phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by 1H NMR, 19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α‐aminophosphonates containing fluorine moiety. |
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| Keywords: | chiral aminophosphonate fluorine moiety antifungal activity microwave irradiation synthesis |
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